Can Jardiance Help With Weight Loss? Here’s What You Need to Know

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Weight gain or loss can result from diabetes, a chronic illness in which blood sugar levels are elevated. You might prioritize exercise and a healthy diet if one of your diabetes management goals is to shed some excess pounds. You may also seek medications that can assist in managing weight and treating diabetes. Jardiance, a medication authorized by the US Food and Drug Administration in 2014 for the treatment of type 2 diabetes, is one example. Despite not being a new medication, there are still many queries regarding it in the midst of the popularity of Ozempic, which functions as a weight reduction and anti-diabetes treatment. Does Jardiance therefore help people lose weight as well?

What is Jardiance?

Empagliflozin, a member of the class of medications known as SGLT2 (sodium-glucose co-transporter-2) inhibitors, is sold under the brand name. Dr. Monika Sharma, an endocrinologist, says, "It works by preventing the kidneys from reabsorbing glucose back into the blood. Instead, it allows excess glucose to be excreted through the urine."

Diabetes is treated with Jardiance. Adobe Stock provides the picture.

The medication, which is available as oral tablets, should be taken at a dosage of 10 mg once daily in the morning, as advised. It can be taken with or without meals. "Depending on your condition and tolerance, your doctor may increase it to 25 mg once daily," says the expert.

What purpose does Jardiance serve?

Does Jardiance result in weight loss? Before we answer the question, let us first explain the drug's main application:

Type 2 diabetes management, as it aids in regulating blood glucose levels by promoting glucose excretion via urine. In addition to lifestyle changes like diet and exercise programs, the doctor recommends it.

Lowering the likelihood of hospitalization or mortality for heart failure patients since it can lessen fluid excess and enhance heart function. According to the specialist, "This is possible because of its diuretic-like effect that can lower the strain on the heart."

It is ineffective at treating type 1 diabetes.

Is weight loss a side effect of Jardiance?

Ozempic and other anti-diabetes drugs can aid in weight reduction. "Does Jardiance cause weight loss?" you may wonder. Dr. Sharma responds, "It may lead to modest weight loss in some people." Individuals who used Jardiance either by itself or in conjunction with other diabetes medications lost between 1.8% and 3.2% of their body weight throughout the course of a study. According to the US Food and Drug Administration, this weight loss was seen over the course of 24 weeks.

The following are the causes of the weight reduction effect:

Glucose excretion: Jardiance prevents glucose reabsorption, which causes the body to eliminate too much sugar in the urine. The expert claims that "this also leads to a loss of calories, about 200 kcal per day, which over time contributes to weight loss."

Does Jardiance aid in weight reduction? Dr. Sharma answers, "Yes, since it causes mild fluid loss through increased urination, which may lead to an initial drop in weight, but this is mostly water weight."

Is weight reduction possible with Jardiance, similar to Ozempic?

The expert claims that, overall, semaglutide, sold under the brand name Ozempic, is more effective for weight loss than Jardiance. According to studies that were published in The Journal Of Clinical Endocrinology And Metabolism, a once-weekly 1 mg dosage of semaglutide produced a greater weight loss in patients with type 2 diabetes than a once-daily 25 mg dose of empagliflozin.

The expert advises, "Ozempic is a GLP-1 (glucagon-like peptide-1) receptor agonist that directly lowers appetite, slows gastric emptying, and reduces food intake." Jardiance, on the other hand, causes weight reduction primarily by causing calorie loss in urine and mild fluid loss. Therefore, if weight loss is your main goal and you don't have contraindications to GLP-1 receptor agonists, use Ozempic for weight loss rather than Jardiance.

Is weight loss a result of Jardiance? Photo credit: Adobe Stock

What are the adverse effects of Jardiance?

More urination: The anti-diabetes medicine causes extra glucose to be eliminated through the urine, resulting in more urine output because glucose draws water along with it (osmotic diuresis).

Genital yeast infections: High glucose concentrations in the urine provide the ideal conditions for fungal development, particularly Candida species in the genitalia.

Urinary tract infections: An abundance of glucose in the urine can provide nourishment to bacteria, raising the possibility of bacterial infections in the urinary tract. According to the Canadian Agency for Drugs and Technologies in Health, one of the most prevalent side effects of empagliflozin is urinary tract infection (UTI).

Dehydration: Because of the osmotic diuresis, the body loses more water. According to the expert, dehydration can result in dizziness and dry mouth if fluid intake does not compensate for fluid lost in urine.

Hypotension, or low blood pressure: Increased urination causes fluid loss, which can result in a decrease in blood volume and blood pressure.

Acute kidney injury: The diuretic effect of Jardiance might cause a transient kidney injury in some individuals, particularly those who are already dehydrated or using other drugs that have an impact on the kidneys, by lowering blood flow to the kidneys.

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